CHRNA1 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	Western blot: 0.75 μg/ml. Immunohistochemistry on Paraffin Sections (1-2.0 μg/ml). Antigen retrieval by heat is recommended.
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	A synthetic peptide corresponding to a sequence at the N-terminal of Human CHRNA1, identical to the related Rat and Mouse sequence
Specificity	Recognizes CHRNA1
Isotype	IgG
Formulation	5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal and 0.05mg Sodium Azide State: Aff - Purified State: Lyophilized purified IgG fraction
Reconstitution Method	Restore with 0.2 ml of distilled water to yield a concentration of 0.5 mg/ml.
Concentration	0.5 mg/ml (after reconstitution)
Purification	Immunoaffinity Chromatography
Conjugation	Unconjugated
Storage Condition	Store the antibody after reconstitution at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	cholinergic receptor nicotinic alpha 1 subunit
Database Link	Entrez Gene 11435 MouseEntrez Gene 79557 RatEntrez Gene 1134 Human UniProt ID P02708
Background	CHRNA, also termed ACHRA, is mapped on 2q24-q32.This gene encodes the alpha subunit of the muscle acetylcholine receptor, which is the main target of pathogenic autoantibodies in autoimmune myasthenia gravis. (1) The protein-coding sequence of the human alpha subu gene is divided into 9 exons that correspond to different structural and functional domains of the precursor molecule. (2)
Synonyms	CHRNA1, ACHRA, CHNRA
Reference Data
Protein Families	Druggable Genome, Ion Channels: Cys-loop Receptors, Transmembrane

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