APAF1 (C-term) Rabbit Polyclonal Antibody

CAT#: AP22708PU-N

APAF1 (C-term) rabbit polyclonal antibody, Purified



Need it in bulk or conjugated?
Get a free quote

CNY 6,116.00


货期*
5周

规格
    • 250 ul

Product images

Specifications

Product Data
Applications IHC
Recommend Dilution Immunohistochemistry on Paraffin Sections: 10 µg/ml.
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Immunogen APAF1 antibody was raised against a synthetic peptide derived from the C-terminus of human Apaf-1
Specificity This antibody reacts to Apoptotic Protease Activating Factor 1 (APAF1).
Formulation 10 mM PBS, pH 7.4, BSA, sodium azide.
State: Purified
State: Liquid purified Ig fraction
Concentration lot specific
Purification Immunoaffinity Chromatography
Conjugation Unconjugated
Storage Condition Store the antibody undiluted at 2-8°C.
DO NOT FREEZE!
Gene Name apoptotic peptidase activating factor 1
Background Apaf1 has been described as the core of the apoptosome. Deficiency in murine Apaf1 leads to embryonic lethality with a phenotype affecting many aspects of developmental apoptosis. In the developing brain, Apaf1 is a death regulator of the neuronal founder cells. Combined intercrosses of mouse lines mutant for members of the mitochondrial death pathway are providing us with some clues about the relative regulation existing among neuronal cell populations. Apaf1-deficient embryos display an interesting phenotype in the inner ear and in limb development, which involves different caspase-dependent and -independent pathways. Moreover, APAF1 is mutated in human melanomas, and its depletion contributes to malignant transformation in a mouse model of cancer.
Synonyms Apaf-1, KIAA0413
Reference Data
Protein Families Druggable Genome
Protein Pathways Alzheimer's disease, Amyotrophic lateral sclerosis (ALS), Apoptosis, Huntington's disease, p53 signaling pathway, Parkinson's disease, Small cell lung cancer
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
Customer Reviews 
Loading...