FOXC1 Goat Polyclonal Antibody
CAT#: AP22375PU-N
FOXC1 goat polyclonal antibody, Aff - Purified
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CNY 5371.00
货期*
4周
规格
| Cited in 3 publications. |
Specifications
| Product Data | |
| Applications | ELISA, WB |
| Recommend Dilution | Peptide ELISA: Detection Limit: 1/32000. Western blot: 2-4 µg/ml. Detects a band of ~55 kDa in lysates of cell line HEK293. |
| Reactivity | Human, Mouse, Porcine |
| Host | Goat |
| Clonality | Polyclonal |
| Immunogen | Dynthetic peptide from an internal region of Human FOXC1 (NP_001444.2). |
| Specificity | Recognizes FOXC1 (internal). |
| Formulation | Tris saline, pH 7.3 containing 0.02% Sodium Azide as preservative and 0.5% BSA as stabilizer. State: Aff - Purified State: Liquid purified IgG fraction. |
| Concentration | lot specific |
| Purification | Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide. |
| Conjugation | Unconjugated |
| Storage Condition | Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. |
| Gene Name | forkhead box C1 |
| Database Link | |
| Background | FOXC1 belongs to the forkhead family of transcription factors which is characterized by a distinct DNA-binding forkhead domain. The specific function of this gene has not yet been determined; however, it has been shown to play a role in the regulation of embryonic and ocular development. Mutations in this gene cause various glaucoma phenotypes including primary congenital glaucoma, autosomal dominant iridogoniodysgenesis anomaly, and Axenfeld-Rieger anomaly. |
| Synonyms | Forkhead box protein C1, FREAC-3 |
| Note | Calculated Molecular Weight: 56.8kDa (NP_001444.2). |
| Reference Data | |
| Protein Families | Druggable Genome, Transcription Factors |
Citations (3)
| The use of this Antibodies has been cited in the following citations: |
|---|
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FOXC1 Regulates Expression of Prostaglandin Receptors Leading to an Attenuated Response to Latanoprost.
,null,
Investigative ophthalmology visual science
,PubMed ID 29847662
[FOXC1]
|
|
FOXC1 modulates MYOC secretion through regulation of the exocytic proteins RAB3GAP1, RAB3GAP2 and SNAP25
,null,
PLoS ONE
,PubMed ID 28575017
[FOXC1]
|
|
Dysfunction of the stress-responsive FOXC1 transcription factor contributes to the earlier-onset glaucoma observed in Axenfeld-Rieger syndrome patients
,null,
Cell Death & Disease
,PubMed ID 24556684
[FOXC1]
|
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