67kDa Laminin Receptor (RPSA) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	Western blot: 1/500 - 1/1000. Immunohistochemistry on paraffin sections: 1/50 - 1/200.
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Specificity	This antibody detects endogenous levels of Laminin-R protein. (region surrounding Gln215)
Formulation	Phosphate buffered saline (PBS), pH 7.2. State: Aff - Purified State: Liquid purified Ig fraction Preservative: 0.05% sodium azide
Concentration	1.0 mg/ml
Purification	Affinity chromatography (> 95% (by SDS-PAGE)
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Predicted Protein Size	~ 40 kDa
Gene Name	ribosomal protein SA
Database Link	Entrez Gene 16785 MouseEntrez Gene 29236 RatEntrez Gene 3921 Human UniProt ID P08865
Background	Laminin receptor (Laminin-R) has a heterodimeric structure similar to that of receptors for other extracellular matrix proteins such as Fibronectin and Vitronectin. Incorporation of Laminin-R into lysosomal membranes makes it possible for lysosomes to attach to surfaces coated with Laminin. This and other properties identify Laminin-R as a member of the integrin family of cell adhesion receptors. The Laminin-R precursor is a polypeptide whose expression is consistently upregulated in aggressive carcinoma. The precursor, which is also identified as p40 ribosome-associated protein, appears to be a multifunctional protein involved in the translational machinery. Laminin-R (also known as colon carcinoma Laminin-binding protein) is found at nine-fold higher levels in colon carcinoma than in adjacent normal colonic epithelium. Addi-tionally, the level of the Laminin-R is higher in the lung cancer cell line than in the lung cell line.
Synonyms	40S ribosomal protein SA, LAMBR, LAMR1, LamR, Laminin receptor 1, 37LRP, LRP/LR, 67LR, NEM/1CHD4
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Ribosome

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