alpha Defensin 1 (DEFA1) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC
Recommend Dilution	Immunohistochemistry on Paraffin Sections: 1/50-1/200.
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Specificity	This antibody detects endogenous levels of Defensin α1 protein. (region surrounding Ser52)
Formulation	Phosphate buffered saline (PBS), pH~7.2 State: Aff - Purified State: Liquid purified Ig fraction (> 95% pure by SDS-PAGE) Preservative: 0.05% Sodium Azide
Concentration	1.0 mg/ml
Purification	Affinity Chromatography using epitope-specific immunogen
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	defensin alpha 1
Database Link	Entrez Gene 728358 HumanEntrez Gene 1667 Human UniProt ID P59665
Background	β-Defensins (also designated BD, and HBD in human) are small cationic peptides with broad-spectrum antimicrobial activity. β-defensins are involved in the resistance of epithelial surfaces, such as airway surface fluid, to microbial colonization. Produced in mucosal epithelia and neutrophils of several species, β-defensins are developmentally regulated. Human β-defensin 1, isolated from the kidney, has a molecular mass of 3.9 kDa. Human β-defensin 1 shares homology with other β-defensins from human blood filtrate and is also present in nanomolar concentrations in human plasma. In addition to the antimicrobial activity of human airway epithelia, β-defensin 1 may play a role in the mucosal defenses of the lung.
Synonyms	Neutrophil defensin 1, HNP-1, DEFA1, DEF1, DEFA2, MRS
Reference Data
Protein Families	Druggable Genome

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