FOXE3 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	Immunohistochemistry on Paraffin sections: 1/50-1/200. Western Blot: 1/500-1/1000.
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Specificity	This antibody detects endogenous levels of FOXE3 protein. (region surrounding Arg97)
Formulation	Phosphate buffered saline (PBS) with 0.05% Sodium azide, approx. pH 7.2. State: Aff - Purified State: Liquid purified Ig fraction
Concentration	1.0 mg/ml
Purification	Affinity chromatography (> 95% (by SDS-PAGE)
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Predicted Protein Size	~ 33 kDa
Gene Name	forkhead box E3
Database Link	Entrez Gene 30923 MouseEntrez Gene 171302 RatEntrez Gene 2301 Human UniProt ID Q13461
Background	The human forkhead-box (FOX) gene family consists of at least 43 members, including FOXE3, a 288-amino acid protein. FOXE3 is a winged-helix transcription factor that plays a crucial role during the initial stages of lens development and closure of the lens vesicle. FOXE3 may also act as a factor that promotes survival and proliferation while preventing differentiation in the lens epithelium. As the posterior cells of the lens fiber begin to differentiate, expression of FOXE3 is limited to the undifferentiated cells coating the anterior surface of the lens. Congenital primary aphakia (CPA) is a rare developmental disorder caused by a null mutation in the FOXE3 gene that is identified by the absence of a lens. The development of CPA is normally stimulated during the fourth or fifth week of human embryogenesis.
Synonyms	Forkhead box protein E3, FREAC8
Reference Data

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.