CDK1 Rabbit Polyclonal Antibody

CAT#: AP20350PU-N

CDK1 rabbit polyclonal antibody, Aff - Purified



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CNY 1,999.00

CNY 4,640.00


货期*
2周

规格
    • 100 ug

Product images

Specifications

Product Data
Applications WB
Recommend Dilution Western blot: 1/500-1/1000.
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Specificity This antibody detects endogenous levels of Cdk1/Cdc2 protein.
Formulation Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2
State: Aff - Purified
State: Liquid purified Ig fraction
Concentration 1.0 mg/ml
Purification Affinity-chromatography using epitope-specific immunogen; purity is > 95% (by SDS-PAGE)
Conjugation Unconjugated
Storage Condition Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Predicted Protein Size ~ 34 kDa
Gene Name cyclin-dependent kinase 1
Background The cell division control protein cdc2, also known as cyclin-dependent kinase 1 (Cdk1) or p34/cdk1, plays a key role in the control of the eukaryotic cell cycle, where it is required for entry into S-phase and mitosis. Cdc2 exists as a complex with both cyclin A and cyclin B. The best characterized of these associations is the Cdc2 p34 cyclin B complex, which is required for the G2 to M phase transition. Activation of Cdc2 is controlled at several steps including cyclin binding and phosphorylation of threonine 161. However, the critical regulatory step in activating cdc2 during progression into mitosis appears to be dephosphorylation of Tyr15 and Tyr14. Phosphorylation at Tyr15 and inhibition of Cdc2 is carried out by WEE1 and MIK protein kinases while Tyr15 dephosphorylation and activation of Cdc2 is carried out by the cdc25 phosphatase. The isoform CDC2deltaT is found in breast cancer tissues. Furthermore, cdc2/Cdk1 is a key mediator of neuronal cell death in brain development and degeneration.
Synonyms CDK1, CDC2, CDC28A, CDKN1, P34CDC2, p34 protein kinase
Reference Data
Protein Families Druggable Genome, Protein Kinase, Stem cell - Pluripotency
Protein Pathways Cell cycle, Gap junction, Oocyte meiosis, p53 signaling pathway, Progesterone-mediated oocyte maturation
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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