P4HB (C-term) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	FC, IHC, WB
Recommend Dilution	ELISA: >1/1,000 (peptide ELISA only) Western blotting: 1/500-1/1000. Flow Cytometry: 1/10-1/50. Immunohistochemistry: 1/50-1/100.
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	KLH conjugated synthetic peptide between 436~464 amino acids from the C-terminal region of Human P4HB.
Specificity	This antibody recognizes Protein Disulfide Isomerase.
Formulation	PBS with 0.09% (W/V) Sodium Azide as preservative State: Liquid purified Ig fraction
Concentration	lot specific
Purification	Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	prolyl 4-hydroxylase subunit beta
Database Link	Entrez Gene 5034 Human UniProt ID P07237
Background	P4HB is a highly abundant multifunctional enzyme that belongs to the protein disulfide isomerase family. When present as a tetramer consisting of two alpha and two beta subunits, this enzyme is involved in hydroxylation of prolyl residues in preprocollagen. This enzyme is also a disulfide isomerase containing two thioredoxin domains that catalyze the formation, breakage and rearrangement of disulfide bonds. Other known functions include its ability to act as a chaperone that inhibits aggregation of misfolded proteins in a concentration-dependent manner, its ability to bind thyroid hormone, its role in both the influx and efflux of S-nitrosothiol-bound nitric oxide, and its function as a subunit of the microsomal triglyceride transfer protein complex.
Synonyms	ERBA2L, PDIA1, PO4DB, Protein disulfide-isomerase, ER marker
Reference Data
Protein Families	Druggable Genome

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