DIO1 (N-term) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	ELISA: 1/1,000. Western blot: 1/1,000.
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	KLH conjugated synthetic peptide between 30~57 amino acids from the N-terminal region of Human DIO1
Specificity	This antibody detects DIO1 at N-term.
Formulation	PBS with 0.09% (W/V) Sodium Azide as preservative State: Liquid purified Ig fraction
Concentration	lot specific
Purification	Protein A column, followed by peptide affinity purification
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	deiodinase, iodothyronine type I
Database Link	Entrez Gene 1733 Human UniProt ID P49895
Background	DIO1 is a thiol-requiring propylthiouracil-sensitive oxidoreductase. It activates thyroid hormone by converting the prohormone thyroxine (T4) by outer ring deiodination (ORD) to bioactive 3,3',5-triiodothyronine (T3). It also degrades both hormones by inner ring deiodination (IRD).
Synonyms	DIOI, ITDI1, TXDI1
Note	Calculated Molecular weight: 28924 Da
Reference Data
Protein Families	Druggable Genome, Transmembrane

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