Sclerostin (SOST) (Center) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	ELISA: 1/1,000. Western Blot: 1/50-1/100 Immunohistochemistry: 1/10-1/50.
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	KLH conjugated synthetic peptide between 141~171 amino acids from the Center region of Human SOST.
Specificity	This antibody recognizes SOST (Center).
Isotype	Ig
Formulation	PBS with 0.09% (W/V) Sodium Azide State: Purified State: Liquid purified Ig fraction
Concentration	lot specific
Purification	Protein A Chromatography, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	sclerostin
Database Link	Entrez Gene 50964 Human UniProt ID Q9BQB4
Background	Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Loss-of-function mutations in this gene are associated with an autosomal-recessive disorder, sclerosteosis, which causes progressive bone overgrowth. A deletion downstream of the sclerostin gene, which causes reduced sclerostin expression, is associated with a milder form of the disorder called van Buchem disease.
Synonyms	sclerosteosis; sclerostin; VBCH
Reference Data

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