Presenilin 1 (PSEN1) (C-term) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, IHC, WB
Recommend Dilution	ELISA: 1/1,000. Western blot: 1/100 - 1/500. Immunohistochemistry on paraffin sections: 1/50 - 1/100.
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human PSEN1.
Specificity	This antibody reacts to Presenilin 1 (PSEN1).
Isotype	Ig
Formulation	PBS with 0.09% (W/V) sodium azide State: Purified State: Liquid purified Ig fraction
Concentration	lot specific
Purification	Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	presenilin 1
Database Link	Entrez Gene 5663 Human UniProt ID P49768
Background	Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes.
Synonyms	Presenilin 1, PSEN1, PS1, AD3, Alzheimer Disease 3, PS-1, PSNL1, AF3, FAD, S182
Reference Data

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