TAK1 (MAP3K7) pSer192 Rabbit Polyclonal Antibody

Specifications

Product Data
Recommend Dilution	Dot Blot: 1/100-1/500.
Reactivity	Bovine, Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Ser192 of Human MAP3K7.
Specificity	This antibody detects TAK1 / MAP3K7 pSer192.
Isotype	Ig
Formulation	PBS State: Aff - Purified State: Liquid purified Ig fraction Preservative: 0.09% (W/V) Sodium Azide
Concentration	lot specific
Purification	Protein A Chromatography followed by two-step phosphospecific peptide affinity purification
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	mitogen-activated protein kinase kinase kinase 7
Database Link	Entrez Gene 6885 Human UniProt ID O43318
Background	MAP3K7 is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses.
Synonyms	TAK1, TGF-beta-activated kinase 1, TAK-1
Note	Molecular weight: 67196 Da
Reference Data

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