Plakophilin 4 (PKP4) (Peptide 1-1 to 1-4) Guinea Pig Polyclonal Antibody

Specifications

Product Data
Applications	IF, IHC, WB
Recommend Dilution	Western Blot: 1/1000. Immunofluorescence: 1/100. Immunohistochemistry on frozen and paraffin sections. Immunoelectron microscopy. Incubation time: 1-1.5 h at RT
Reactivity	Bovine, Human, Mouse
Host	Guinea Pig
Clonality	Polyclonal
Immunogen	Synthetic peptide cocktail of human p0071: Peptide 1-1 to 1-4 (aa positions: aa 85-104; aa 173-193; aa 359-382; aa 407-430)
Specificity	Stains an armadillo plaque protein that characterizes a specific subtype of adherens junctions and their functions. This plaque protein (p0071) is specific for a subtype of adherens junctions, with a molecular mass of 135 kD. p0071 is specifically detected in the plaques of the composite junctions (area compositae) of cardiac intercalated disks, in puncta adhaerentia of single- and multi-layered epithelia and blood vessel endothelial cells.; it is, however, absent from desmosomes. Recommended Positive Control: MCF-7. Reactivities on cultured cell lines (tested so far): MCF-7, MH1C1, 3T3, RVF-SMV.
Formulation	State: Serum State: Liquid stabilized antiserum containing 0.09% sodium azide
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	plakophilin 4
Database Link	Entrez Gene 8502 Human UniProt ID Q99569
Background	Plakophilin 4 (PKP4) is an Armadillo-like protein, characterized by a series of armadillo repeats. It is a component of desmosomal plaques and may play a role in junctional plaque organization.
Synonyms	PKP4, p0071
Reference Data

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