Fractin (C-term) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	Western Blot: 1/1000. Immunohistochemistry: 1/100.
Reactivity	Human, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide taken from the C terminus of the 32-kDa Actin fragment.
Specificity	Specific for the ~ 32 kDa Fractin protein in Western blots with no reactivity to intact actin. There is often a ladder of smaller bands in cells or culture or in vivo preparations due to further degradation by other proteases. The antibody has been shown to detect the processes and cell bodies of degenerating neurons and plaque-associated microglia in Alzheimer's disease. (Ref.1)
Isotype	IgG
Formulation	State: Serum State: Liquid Neat Serum without preservatives.
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted (in aliquots) at -20°C. Avoid repeated freezing and thawing.
Background	Fractin (fragment of Actin) is a Caspase-specific cleavage product of actin and serves as a novel marker of apoptosis-related events. It has recently been reported that Fractin may have a functional role in apoptotic signaling in oligodendrocytes (Schulz, R., et al., Glia, 2009, in press).
Synonyms	Fragment of Actin
Reference Data

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