Synaptophysin (SYP) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC
Recommend Dilution	Immunohistochemistry for Formalin-Fixed Paraffin Embedded (FFPE) Tissue Sections and Frozen Sections: Dilute 1/100-1/200 using polymer or streptavidin ~Biotin system for 30 mins at RT. This antibody requires antigen retriever (boiling FFPE tissue sections in 10mM citrate buffer, pH 6.0 for 10-20 mins. followed by cooling at RT for 20 mins). Positive Control: Human pancreas or GI tumor.
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	A synthetic peptide from C-terminus of Human Synaptophysin.
Specificity	This antibody reacts with Synaptophysin in neuroendocrine neoplasm of neural as well as epithelial type. Cellular localization: Cytoplasmic.
Formulation	10 mM PO4, 150 mM NaCl, pH 7.4 containing 1% BSA as stabilizer and 0.05% Sodium Azide as preservative. State: Purified State: Liquid purified Ig fraction.
Concentration	lot specific
Purification	Protein A Chromatography.
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	synaptophysin
Database Link	Entrez Gene 6855 Human UniProt ID P08247
Background	Synaptophysin is a synaptic vesicle glycoprotein with 4 transmembrane domain MW 38 kDa. Thisproteinis present in the membrane of neuronal presynaptic vesicles in brain, spinal cord, retina, vesicles of adrenal medulla, neuromuscular junctions, and endocrine cells. It is also expressed by neuroendocrine cells throughout the body, both normal and neoplastic. Synaptophysin is also marker of endocrine tumors. It is a useful marker for the identification of normal neuroendocrine cells and neuroendocrine neoplasms.
Synonyms	Neuroendocrine Marker
Reference Data

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