Tyrosine Hydroxylase (TH) Rabbit Polyclonal Antibody

CAT#: AP06420PU-S

Tyrosine Hydroxylase (TH) rabbit polyclonal antibody, Aff - Purified

Size: 100 ug 25 ul



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CNY 800.00


货期*
2周

规格
    • 25 ul

Product images

Specifications

Product Data
Applications IHC, WB
Recommend Dilution Western blot: 1/500-1/1000.
Immunohistochemistry on paraffin sections: 1/50-1/200.
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Immunogen Synthetic peptide, corresponding to the N-terminus of Human TH.
Specificity This antibody detects endogenous levels of Tyrosine Hydroxylase protein.
(region surrounding Gln25)
Formulation Phosphate buffered saline (PBS), pH 7.2.
State: Aff - Purified
State: Liquid purified Ig fraction
Preservative: 0.05% sodium azide
Concentration 1.0 mg/ml
Purification Affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE)
Conjugation Unconjugated
Storage Condition Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Predicted Protein Size ~ 58 kDa
Gene Name tyrosine hydroxylase
Background The enzyme tyrosine hydroxylase (TH), also designated tyrosine 3-monooxygenase (TY3H), catalyzes the conversion of tyrosine to L-dopa, which is the rate limiting step in the biosynthesis of catecholamines such as dopamine, adrenalin and noradrenalin. TH is thought to play a role in the pathogenesis of Parkinson’s disease, which is associated with reduced dopamine levels. Two transcription factor binding sites in the proximal region of the TH gene, the TPA-responsive element (TRE) and the c-AMP responsive element (CRE), have been implicated in the complex regulation of the TH gene. TH is also known to be upregulated by the glia maturation factor (GMF), a Cdc 10/SWI6 motif-containing protein called V-1, and a variety of additional compounds.
Synonyms Tyrosine 3-hydroxylase, TYH
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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