Tryptophan Hydroxylase (TPH1) Sheep Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	Immunohistochemistry on frozen sections: 1:1000. Western Blot: 1:1000; detects a band of approximately 55kDa in human dorsal Raphe nucleus lysates.
Reactivity	Human, Rat
Host	Sheep
Clonality	Polyclonal
Immunogen	Recombinant rabbit Tryptophan Hydroxylase purified from E. coli.
Specificity	This antibody recognises Tryptophan Hydroxylase (TPH) which catalyses the 5-hydroxylation of tryptophan, in the first stage of indoleamine biosynthesis. Serotonin biosynthesis occurs principally in neurons which originate in the raphe nucleus of the brain, and melatonin synthesis takes place within the pineal gland.
Formulation	10mM HEPES, pH7.5 containing 0.09% Sodium Azide, 0.01% Bovine Serum Albumin and 50% Glycerol State: Purified State: Liquid purified Ig
Purification	Affinity chromatography
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	tryptophan hydroxylase 1
Database Link	Entrez Gene 7166 Human UniProt ID P17752
Synonyms	Tryptophan 5-monooxygenase 1, TPRH, TRPH
Reference Data

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