DISC1 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, WB
Recommend Dilution	Western blot: 1 - 2 µg/ml; detects bands of approximately 95100kDa in SKNSH cell lysate. Immunocytochemistry.
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	An 18 amino acid peptide located near the centre of human DISC1.
Specificity	This antibody recognises disrupted in schizophrenia 1 (DISC1), 93kD protein located in the nucleus, cytoplasm and mitochondria.
Isotype	IgG
Formulation	Phosphate buffered saline containing 0.02% Sodium Azide State: Purified State: Liquid purified IgG
Concentration	lot specific
Purification	Affinity chromatography
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for up to one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	disrupted in schizophrenia 1
Database Link	Entrez Gene 27185 Human UniProt ID Q9NRI5
Background	The DISC1 protein is widely expressed in normal tissues. It is involved in neurite outgrowth and cortical development through its interaction with a variety of proteins including lissencephaly-1 (LIS1), NudeE-like (NUDEL) and phosphodiesterase 4B. In certain cases of schizophrenia the DISC1 gene has been found to be disrupted by a t(1;11) (q42.1;q14.3) translocation, and studies suggest that DISC1 could be a candidate susceptibility gene for this condition.
Synonyms	DISC-1, KIAA0457, Disrupted in schizophrenia 1 protein
Reference Data

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