Cacna1a Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	Western Blot: 1/400. Positive Control: Rat brain lysate.
Reactivity	Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide derived from the rat alpha-1A Calcium Channel conjugated to KLH.
Specificity	This antibody recognizes a1A Calcium Channel.
Isotype	IgG
Formulation	Phosphate Buffered Saline with 0.08% Sodium Azide as preservative. State: Aff - Purified State: Liquid purified Ig fraction.
Concentration	lot specific
Purification	Immunoaffinity Chromatography.
Conjugation	Unconjugated
Storage Condition	Store the product (in aliquots) at -20°C. Avoid repeated freezing and thawing.
Gene Name	calcium voltage-gated channel subunit alpha1 A
Database Link	Entrez Gene 25398 Rat UniProt ID P54282
Background	Voltage-sensitive calcium channels (VSCCs) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1a gives rise to p and/or q-type calcium currents. P/q-type calcium channels belong to the 'high-voltage activated' (hva) group and are blocked by the funnel toxin (ftx) and by the omega-agatoxin-IVA (omega-aga-IVA). They are however insensitive to dihydropyridines (dhp), and omega- conotoxin-GVIA (omega-ctx-GVIA). voltage-dependent calcium channels are multisubunit complexes, consisting of alpha-1, alpha-2, beta and delta subunits in a 1:1:1:1 ratio. The channel activity is directed by the pore-forming and voltage-sensitive alpha-1 subunit. In many cases, this subunit is sufficient to generate voltage-sensitive calcium channel activity. The auxiliary subunits beta and alpha-2/delta linked by a disulfide bridge regulate the channel activity.
Synonyms	Cav2.1, Brain calcium channel I, CACH4, CACN3, CACNL1A4
Reference Data

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