DEGS1 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	Western Blot (1/400 starting dilution). Immunohistochemistry (10-15 μg/ml). Positive Control: Placenta, normal Human brain.
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide derived from the Human DEGS1 protein
Specificity	This antibody detects Degenerative Spermatocyte Homolog 1.
Isotype	IgG
Formulation	PBS State: Aff - Purified State: Liquid purified Ig fraction Preservative: 0.08% Sodium Azide
Concentration	lot specific
Purification	Antigen Immunoaffiinity Chromatography
Conjugation	Unconjugated
Storage Condition	Upon receipt, store undiluted (in aliquots) at -20°C. Avoid repeated freezing and thawing.
Gene Name	delta(4)-desaturase, sphingolipid 1
Database Link	Entrez Gene 13244 MouseEntrez Gene 58970 RatEntrez Gene 8560 Human UniProt ID O15121
Background	The product of the DEGS1 gene is a member of the membrane fatty acid (sphingolipid delta 4) desaturase family. Reported to function by inserting double bonds at delta 4 position in fatty acids. DEGS1 is an intracellular enzyme. Overexpression of this gene inhibited biosynthesis of the EGF receptor, suggesting a possible role of a fatty acid desaturase in regulating biosynthetic processing of the EGF receptor. Two splice variants have been identified.
Synonyms	DES1, MLD, MIG15, Degenerative spermatocyte homolog 1, Membrane lipid desaturase
Reference Data
Protein Families	Druggable Genome, Transmembrane
Protein Pathways	Metabolic pathways, Sphingolipid metabolism

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