CACNA1E Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	Western Blot: 5-10 µg/ml.
Reactivity	Human, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide derived from the Rat alpha1E Calcium Channel conjugated to KLH.
Specificity	This antibody recognizes Alpha 1E Calcium Channel CACNA1E.
Isotype	IgG
Formulation	PBS State: Purified State: Liquid purified Ig fraction Preservative: 0.08% Sodium Azide
Concentration	lot specific
Purification	Ammonium sulfate precipitation
Conjugation	Unconjugated
Storage Condition	The antibody can be shipped at ambient temperature. Store (in aliquots) at -20°C only. Avoid repeated freezing and thawing.
Gene Name	calcium voltage-gated channel subunit alpha1 E
Database Link	Entrez Gene 777 Human UniProt ID Q15878
Background	Voltage-sensitive calcium channels (VSCCs) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents. R-type calcium channels belong to the 'high-voltage activated' (hva) group and are blocked by nickel, and partially by omega-agatoxin-iiia (omega-aga-IIIA). They are however insensitive to dihydropyridines (DHP), omega-conotoxin-GVIA (omega-ctx-GVIA), and omega-agatoxin-IVA (omega-aga-IVA). Calcium channels contaning alpha-1e subunit could be involved in the modulation of firing patterns of neurons.
Synonyms	CACH6, CACNL1A6, Cav2.3, Brain calcium channel II
Reference Data

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