AKAP12 / SSeCKS Sheep Polyclonal Antibody

Specifications

Product Data
Applications	IHC, IP, WB
Recommend Dilution	Western Blot: 2-5 µg/ml. Immunoprecipitation. Immunohistochemistry.
Reactivity	Bovine, Rat
Host	Sheep
Clonality	Polyclonal
Immunogen	Recombinant protein corresponding to amino acids 620-1596 of the SSeCKS protein.
Specificity	This antibody reacts to SSeCKS (Src-Suppressed C Kinase Substrate).
Formulation	Phosphate buffered saline with 0.08% Sodium Azide as preservative. State: Purified State: Liquid purified Ig fraction.
Concentration	lot specific
Purification	Ammonium Sulfate Precipitation.
Conjugation	Unconjugated
Storage Condition	The antibody can be shipped at ambient temperature. Store (in aliquots) at -20°C only. Avoid repeated freezing and thawing.
Database Link	UniProt ID Q62766
Background	Activation of protein kinase C is a key signal transduction event in mesangial cell dedifferentiation and proliferation, yet little is known about downstream substrates or their roles in normal or diseased states. SSeCKS, a novel protein kinase C substrate originally isolated as a src-suppressed negative mitogenic regulator in fibroblasts, controls actinbased cytoskeletal architecture and scaffolds key signaling kinases such as protein kinase C and protein kinase A. Activation of protein kinase C is a key signal transduction event in mesangial cell dedifferentiation. A role for SSeCKS, a PKA/PKC scaffolding protein, has been implicatedduring the process of spermiogenesis and in the actinbased stellate morphology of mesangial cells.
Note	Predicted Molecular Weight: 172.5 kDa
Reference Data

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