STAT5A pTyr694 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	Western blot: 1/500-1/1000. Immunohistochemistry on Paraffin Sections: 1/50-1/100.
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthesized phosphopeptide derived from Human STAT5A around the phosphorylation site of Tyrosine 694 (D-G-Yp-V-K).
Specificity	This antibody detects endogenous levels of STAT5A only when phosphorylated at Tyrosine 694.
Formulation	PBS (without Mg2+ and Ca2+), pH 7.4, 150 M NaCl State: Aff - Purified State: Liquid purified Ig fraction Stabilizer: 50% Glycerol Preservative: 0.02% Sodium Azide
Concentration	lot specific
Purification	Immunoaffinity Chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
Conjugation	Unconjugated
Storage Condition	Store the antibody (in aliquots) at -20°C. Avoid repeated freezing and thawing.
Predicted Protein Size	90 kDa
Gene Name	signal transducer and activator of transcription 5A
Database Link	Entrez Gene 6776 Human UniProt ID P42229
Background	The STAT proteins serve as both cytoplasmic signal transducers and nuclear activators of transcription. STATs are mediators involved in cytokine signalling. In response to a specific cytokine signal, STAT proteins are phosphorylated on conserved tyrosine residues. Phosphorylated STAT proteins dimerize via their SH2 domains and move to the nucleus. The STAT dimers bind to specific DNA elements resulting in transcriptional regulation of downstream target genes. STAT5 is activated in response to prolactine, growth hormone, GM-CSF, and IL-2.
Synonyms	STAT-5, STAT-5A, Mammary gland factor, MGF
Reference Data

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