Amyloid Precursor Protein (APP) pThr668 Rabbit Polyclonal Antibody

CAT#: AP01726PU-N

Amyloid Precursor Protein (APP) pThr668 rabbit polyclonal antibody, Aff - Purified

Size: 100 ug 25 ul



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CNY 1,999.00

CNY 4,437.00


货期*
2周

规格
    • 100 ug

Product images

Specifications

Product Data
Applications IF, IHC, WB
Recommend Dilution Western Blot: 1/500-1/1000.
Immunohistochemistry on paraffin sections: 1/50-1/200.
Immunofluorescence: 1/50-1/200.
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Immunogen Synthetic phosphopeptide derived from human APP/β-Amyloid around the phosphorylation site of Threonine 668.
Specificity This antibody detects endogenous levels of Amyloid-beta A4 pThr743/668 protein.
Formulation Phosphate buffered saline (PBS), pH~7.2 containing 0.05% Sodium Azide as preservative.
State: Aff - Purified
State: Liquid purified Ig fraction (> 95% pure by SDS-PAGE).
Concentration 1.0 mg/ml
Purification Affinity Chromatography using epitope-specific immunogen.
Conjugation Unconjugated
Storage Condition Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Predicted Protein Size ~ 70-140 kDa
Gene Name amyloid beta precursor protein
Background Beta Amyloid A4 (APP) is the principle protein implicated in the development of Alzheimer's disease; a debilitating neurodegenerative condition characterized by the loss of cognitive skills and severe behavioral changes (dementia). Beta Amyloid A4 is a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy).
Synonyms Alzheimer disease amyloid protein, Amyloid Precursor Protein, ABPP, APPI, PreA4, Cerebral vascular amyloid peptide, CVAP
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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