GABA B Receptor 1 (GABBR1) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, WB
Recommend Dilution	Western blot: 1/500-1/1000. Immunofluorescence: 1/50-1/200.
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide, corresponding to amino acids 930-950 of Human GABAB R1.
Specificity	This antibody detects endogenous levels of GABBR1 protein (region surrounding Pro931).
Formulation	Phosphate buffered saline (PBS), pH 7.2. State: Aff - Purified State: Liquid purified Ig fraction Preservative: 0.05% Sodium azide
Concentration	1.0 mg/ml
Purification	Affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE)
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Predicted Protein Size	~ 110 kDa
Gene Name	gamma-aminobutyric acid type B receptor subunit 1
Database Link	Entrez Gene 54393 MouseEntrez Gene 81657 RatEntrez Gene 2550 Human UniProt ID Q9UBS5
Background	GAD-65 and GAD-67, glutamate decarboxylases of 65 kDa and 67 kDa, respectively, function to catalyze the production of GABA (gamma-aminobutyric acid). In the central nervous system GABA (gamma-aminobutyric acid) functions as the main inhibitory transmitter by increasing a Cl-conductance that inhibits neuronal firing. GABA has been shown to activate both ionotropic (GABAA) and metabotropic (GABAB) receptors as well as a third class of receptors called GABAC. Both GABAA and GABAC are ligand-gated ion channels, however, they are structurally and functionally distinct. Members of the GABAA receptor family include GABAA Rα1-6, GABAA Rβ1-3, GABAA Rε , GABAA Rδ, GABAA Rγ1-3, GABAA Rρ1 and GABAA Rρ2. The GABAB family is composed of GABAB R1α and GABAB R1β. GABA transporters have also been identified and include GABA T-1, GABA T-2 and GABA T-3 (also designated GAT-1, -2, and -3). The GABA transporters function to terminate GABA action.
Synonyms	GABA-B receptor 1, GABA-B-R1, GABA-BR1, GABABR1, Gb1, GPRC3A
Reference Data
Protein Families	Druggable Genome, GPCR, Secreted Protein, Transmembrane
Protein Pathways	Neuroactive ligand-receptor interaction

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.