RAIDD (CRADD) Mouse Monoclonal Antibody [Clone ID: AT14G8]

Specifications

Product Data
Clone Name	AT14G8
Applications	ELISA, ICC/IF, WB
Recommend Dilution	This antibody has been tested by ELISA, Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended Starting Dilution: 1/500.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant human CRADD (1-199aa) purified from E. coli
Formulation	Liquid in. Phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% glycerol
Concentration	1mg/ml (determined by BCA assay)
Purification	By protein-A affinity chromatography
Conjugation	Unconjugated
Storage Condition	Can be stored at +2°C to +8°C for 1 week. For long term storage, aliquot and store at -20°C to -80C. Avoid repeated freezing and thawing cycles.
Gene Name	CASP2 and RIPK1 domain containing adaptor with death domain
Database Link	NP_003796 Entrez Gene 1116 HumanEntrez Gene 8738 Human UniProt ID P78560
Background	CRADD, also referred as RAIDD, is an adaptor protein that could interact with both caspase 2 and RIP that can promote apoptosis once activated. RAIDD (RIP-associated ICH-1/Ced-3 homologous protein with a death domain) has been identified as a RIP binding protein that also associates with members of the caspase family, providing a link between activation of the TNF-Rs and the triggering of the cysteine protease cascade. The amino-terminal domain of RAIDD shares significant homology with the prodomain of ICH-1 and mediates the binding of RAIDD to this cysteine protease.
Synonyms	Caspase and RIP adapter with death domain, RAIDD, CRADD, Caspase and RIP adapter with death domain, Caspase and RIP adapter with death domain CASP2 and RIPK1 domain containing adaptor with death domain, Death adaptor molecule RAIDD, Death domain containing protein CRADD, MGC9163, RIP associated ICH1/CED3 homologous protein with death domain, RIP associated protein with a death domain.
Reference Data
Protein Families	Secreted Protein

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