Glutathione Reductase (GSR) Mouse Monoclonal Antibody [Clone ID: AT11D10]

Specifications

Product Data
Clone Name	AT11D10
Applications	ELISA, FACS, ICC/IF, WB
Recommend Dilution	The antibody has been tested by ELISA, Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended starting dilution is 1:500.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant human GSR (43-522aa) purified from E.coli
Isotype	IgG1, kappa
Formulation	Liquid in. Phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% glycerol
Concentration	1mg/ml (determined by BCA assay)
Purification	By protein-A affinity chromatography
Conjugation	Unconjugated
Storage Condition	Can be stored at +2°C to +8°C for 1 week. For long term storage, aliquot and store at -20°C to -80C. Avoid repeated freezing and thawing cycles.
Gene Name	glutathione reductase
Database Link	NP_000628 Entrez Gene 2936 Human UniProt ID P00390
Background	Glutathione reductase (GR) also known as glutathione-disulfide reductase (GSR) is an enzyme that in humans is encoded by the GSR gene. Glutathione reductase catalyzes the reduction of glutathione disulfide (GSSG) to the sulfhydryl form glutathione (GSH), which is a critical molecule in resisting oxidative stress and maintaining the reducing environment of the cell. Glutathione reductase functions as dimeric disulfide oxidoreductase and utilizes an FAD prosthetic group and NADPH to reduce one mole of GSSG to two moles of GSH.
Synonyms	Glutathione reductase, GLuR, GRD1
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Glutathione metabolism

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