CD1B Mouse Monoclonal Antibody [Clone ID: RIV12]

Specifications

Product Data
Clone Name	RIV12
Applications	FC, IF, IHC, IP
Recommend Dilution	ELISA: Use BSA free Antibody for coating. Flow Cytometry: 0.5-1 μg/million cells. Immunofluorescence: 1-2 μg/ml. Immunoprecipitation: 1-2 μg/500 μg protein. Functional Studies: Use Antibody without BSA and Azide. Immunohistochemistry on Frozen Sections: 0.5-1 μg/ml for 30 min at RT. Positive Control: MOLT4 cells. Human thymus.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Human peripheral lymphocytes.
Specificity	The Mouse monoclonal antibody recognizes CD1b, a 44kDa type I glycoprotein associated with beta 2-microglobulin. It is expressed on dendritic cells, Langerhans cells, thymocytes, and T acute lymphoblastic leukemia cells. The CD1 multigene family encodes five forms of the CD1 T-cell surface glycoprotein in human, designated CD1A, 1B, 1C, 1D and 1E. CD1, a type 1 membrane protein, has structural similarity to the MHC class I antigen and has been shown to present lipid antigens for recognition by T lymphocytes. Constitutive endocytosis of CD1B molecules and the differential sorting of MHC class II from lysosomes separate peptide- and lipid antigen-presenting molecules during dendritic cell maturation. CD1B is also expressed in interdigitating cells. Cellular Localization: Cell surface.
Isotype	IgG1
Formulation	10mM PBS State: Purified State: Liquid purified IgG fraction from Bioreactor Concentrate Stabilizer: 0.05% BSA Preservative: 0.05% Sodium Azide
Concentration	lot specific
Purification	Protein A/G Chromatography
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C.
Predicted Protein Size	44 kDa
Gene Name	CD1b molecule
Database Link	Entrez Gene 910 Human UniProt ID P29016
Synonyms	CD1; CD1A; MGC125990; MGC125991; R1
Reference Data

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