FBP2 Mouse Monoclonal Antibody [Clone ID: AT1E11]

Specifications

Product Data
Clone Name	AT1E11
Applications	ELISA, WB
Recommend Dilution	The antibody has been tested by ELISA, Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended dilution range for Western blot analysis is 1:500 ~ 1:5000. Recommended starting dilution is 1:1000.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant human FBP2 (1-339aa) purified from E. coli
Isotype	IgG1, kappa
Formulation	Liquid in. Phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% glycerol
Concentration	1mg/ml (determined by BCA assay)
Purification	By protein-G affinity chromatography
Conjugation	Unconjugated
Storage Condition	Can be stored at +2°C to +8°C for 1 week. For long term storage, aliquot and store at -20°C to -80C. Avoid repeated freezing and thawing cycles.
Gene Name	fructose-bisphosphatase 2
Database Link	NP_003828 Entrez Gene 8789 Human UniProt ID O00757
Background	FBP2 (Fructose-1, 6-bisphosphatase isozyme 2) is a 339 amino acid protein. FBP2 belongs to the FBPase class 1 family. The hydrolysis of fructose-1, 6-bisphosphate to fructose-6-phosphate is a key reaction of carbohydrate metabolism. The enzyme that catalyzes this reaction appears to be present in all forms of living organisms. FBPase is encoded by two genes, FBP1 and FBP2, which express the liver and muscle isoforms, respectively. FBPase is regulated by AMP inhibition in most species. Inhibition of FBPase by AMP affects the turnover of bound substrate and not its affinity for substrate.
Synonyms	Fructose-16-bisphosphatase isozyme 2, Fructose-1,6-bisphosphatase isozyme 2
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Fructose and mannose metabolism, Glycolysis / Gluconeogenesis, Insulin signaling pathway, Metabolic pathways, Pentose phosphate pathway

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