Ptprc (CD45RC) Mouse Monoclonal Antibody [Clone ID: HIS25]

Specifications

Product Data
Clone Name	HIS25
Applications	IF, IHC
Recommend Dilution	Flow cytometry. Immunofluorescence. Immunohistochemistry on frozen tissue sections.
Reactivity	Rat
Host	Mouse
Clonality	Monoclonal
Specificity	The antibody recognizes CD45RC, found on B cells, precursor B cells, subset T cells (not thymocytes).
Isotype	IgG1
Formulation	State: Supernatant State: Liquid cell culture supernatant containing 0.09% sodium azide
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C.
Gene Name	protein tyrosine phosphatase, receptor type, C
Database Link	Entrez Gene 24699 Rat UniProt ID P04157
Background	The CD45 family of cell surface glycoprotein antigens exist as a set of isoforms. The patterns of monoclonal antibody recognition of the CD45 phenotypes can be restricted (CD45RA, RB and RC), or broader, such as the CD45 T 200 species. The "restricted" subsets of this group arise as a result of translation of alternatively spliced mRNAs from exons A, B and C (exons 4, 5 and 6), where exons 3-15 encode the extracellular domain of the CD45 molecule. The restricted epitopes are differentially expressed on T and B lymphocytes, including functionally distinct T cells. CD45 (LCA) is a transmembrane phosphotyrosine phosphatase expressed on leucocytes. Myeloid cells do not express the RC isoform.
Synonyms	PTPRC, Leukocyte common antigen, L-CA, T200
Reference Data

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