MHC Class I Mouse Monoclonal Antibody [Clone ID: BRA-23/9]

Specifications

Product Data
Clone Name	BRA-23/9
Applications	FC, IHC
Recommend Dilution	Flow Cytometry. Immunohistochemistry Frozen Sections.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	REH cells, a Human pre-B cell leukaemia cell line.
Specificity	The antibody BRA-23/9 is directed against a non-polymorphic determinant of Human HLA Class I. The antibody has not been tested for cross reactivity with other species. The BRA-23/9 antibody is suitable for the detection of HLA Class I antigen by Flow Cytometry and Immunohistochemistry on Frozen tissues, for example from human tonsil, lymph nodes, as well as lymphocytes.
Isotype	IgG2a
Formulation	PBS State: Purified State: Liquid purified IgG fraction Stabilizer: 0.2% BSA, 50% Glycerol Preservative: 0.02% Sodium Azide
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Background	The major histocompatibility complex (MHC) is a cluster of genes that play an important role in the immune response. In humans, this complex is referred to as the Human Leucocyte Antigen (HLA) system. There are three major HLA class I genes which are HLA-A, HLA-B and HLA-C. These are highly polymorphic and thousands of alleles are known to exist. The HLA-A, B and C gene products are heterodimeric cell surface glycoproteins which all consist of a 40-45kD MHC-encoded alpha chain and a non-covalently linked non-MHC encoded light chain (b2-microglobulin) of 12kDa. These proteins are found on the surface of almost all nucleated cells and their role is to present peptides, produced by intracellular protein degradation, to cytotoxic T lymphocytes and natural killer cells.
Synonyms	HLA Class 1, MHC Class 1, Major Histocompatibility complex class I
Reference Data

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