TIAM1 Mouse Monoclonal Antibody [Clone ID: F5S F6.2]

Specifications

Product Data
Clone Name	F5S F6.2
Applications	IHC, WB
Recommend Dilution	Western Blot. Immunohistochemistry on Frozen Sections.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	T-cell lymphoma invasion and metastasis-inducing protein 1 (Tiam1).
Specificity	This antibody clone F5S F6.2 is directed against the N-terminal region of Tiam1.
Isotype	IgG2b
Formulation	PBS State: Purified State: Liquid purified IgG fraction Preservative: 0.09% Sodium Azide
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	T-cell lymphoma invasion and metastasis 1
Database Link	Entrez Gene 7074 Human UniProt ID Q13009
Background	Tiam1, also known as T-cell lymphoma invasion and metastasis-inducing protein 1, is a protein that in humans is encoded by the TIAM1 gene. TIAM1 is tightly associate with BAIAP2 as a subunit. It contains one DH (DBL-homology) domain, one PDZ domain, two PH domains and one Ras-binding RBD domain. TIAM1 modulates the activity of Rho GTP-binding proteins and connects extracellular signals to cytoskeletal activities. In addition, TIAM1 activates Rac1, CDC42, and to a lesser extent RhoA. TIAM1 is found in virtually all tumor cell lines examined including B- and T-lymphomas, neuroblastomas, melanomas and carcinomas.
Synonyms	TIAM-1
Reference Data

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