Doublecortin (DCX) Mouse Monoclonal Antibody [Clone ID: 3E1]

Specifications

Product Data
Clone Name	3E1
Applications	IF, WB
Recommend Dilution	Western Blot: 1/5000.  Immunofluorescence:  1/1000.
Reactivity	Bovine, Human, Mouse, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Full length recombinant Human Doublecortin expressed in and purified from E. coli.
Specificity	Specific for the ~35 and 45 k Doublecortin protein.
Formulation	PBS State: Aff - Purified State: Liquid purified IgG fraction from Tissue Culture Supernatant. Preservative: 10mM Sodium Azide
Purification	Affinity Chromatography
Conjugation	Unconjugated
Storage Condition	Upon receipt, store undiluted (in aliquots) at -20°C. Avoid repeated freezing and thawing.
Gene Name	doublecortin
Database Link	Entrez Gene 1641 Human UniProt ID O43602
Background	Doublecortin, or DCX, is a microtubule associated protein that is expressed almost exclusively in very early neuronal development (Brown et al., 2003), making it an excellent marker for developing neuronal cells. Defects in the DCX gene lead to X-linked lissencephaly which is characterized by a lack of normal folds on the surface of the brain resulting in a smooth cerebral cortex caused by abnormal migration of neurons during development (des Portes et al., 1998; Gleeson et al., 1998).
Synonyms	Lissencephalin-X, Doublin, DCX, DBCN, LISX
Reference Data

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