IL12A Mouse Monoclonal Antibody [Clone ID: B-S35]

Specifications

Product Data
Clone Name	B-S35
Applications	ELISA
Recommend Dilution	ELISA.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	EBI3 recombinant protein and IL-35/Fc recombinant protein. Myeloma X63/AG.8653 x Balb/c node cells.
Specificity	Recognises both natural and recombinant protein (no cross reaction with IL-12 and IL-27).
Isotype	IgG1
Formulation	PBS without carriers and preservatives State: Azide Free State: Liquid purified (0.2 μm sterile filtered) IgG fraction
Concentration	lot specific
Purification	Ion Exchange Chromatography
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C.
Gene Name	interleukin 12A
Database Link	Entrez Gene 3592 Human UniProt ID P29459
Background	IL-35 or Interleukin 35 is a cytokine belonging to the IL12 family, that is produced by regulatory T cells. It is a dimeric protein composed of IL-12-alpha and IL-27-beta chains. Members of this class of cytokines are important in influencing T helper cell differentiation and supressing inflammatory response. IL-35 is known to play an essential role in immune regulation of the CD4+CD25+ regulatory T (Treg) cells, from which IL-35 is also specifically produced. IL-35 is able to expand CD4+CD25+ Treg cells whereas it can inhibit proliferation of CD4+CD25- effector T (Teff) cells and development of proinflammatory Th17 cells, suppressing inflammatory responses.
Synonyms	IL-12A, IL-12 subunit p35, NKSF1, CLMF p35
Reference Data

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