CD11a (ITGAL) Mouse Monoclonal Antibody [Clone ID: 87-6F9]

Specifications

Product Data
Clone Name	87-6F9
Applications	IHC
Recommend Dilution	Flow Cytometry. Immunohistochemistry on frozen section.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	A BALB/c mouse was immunized and SP2/0 cells were used for fusion with splenocytes.
Specificity	This antibody reacts to CD11a.
Isotype	IgG2b
Formulation	PBS State: Purified State: Liquid purified Ig fraction Preservative: 0.05% sodium azide
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C.
Gene Name	integrin subunit alpha L
Database Link	Entrez Gene 3683 Human UniProt ID P20701
Background	CD11a is expressed on lymphocytes, granulocytes, monocytes and macrophages with increase in levels on memory T cells. CD11a or LFA-1 has a key role in mediating leukocyte adhesion to endothelium during inflammatory responses through binding to ICAM-1 (CD54). Other ligands are ICAM-2 and ICAM-3. It is also involved in many T cell functions and immune phenomena. Mol. weight in SDS gels is about 180 kD. Part of heterodimer with CD18 (integrin beta-2). A defect in beta-2 expression results in leucocytes adhesion deficiency (LAD) in which patients suffer from recurring bacterial infections.
Synonyms	Integrin alpha-L, LFA1, LFA-1
Reference Data

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