HLA Class II DR Mouse Monoclonal Antibody [Clone ID: LN-3]

Specifications

Product Data
Clone Name	LN-3
Applications	IHC
Recommend Dilution	Immunohistochemistry on Paraffin Sections: 1/100. Positive Control: Human Spleen. LN-3 can be applied for the identification of HLA-DR positive germinal center derived B cell lymphomes, HLA-DR positive T cell lymphomas, HLA-positive leukemias and solid tumors in B5 fixed, paraffin embedded tissue.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Human leukocyte antigen-DR
Specificity	This antibody reacts with Human leukocyte antigen-DR (HLA-DR). The antibody clone LN-3 has lymph node germinal center and mantle zone B cell reactivity. It reacts with interdigitating histiocytes in T cell zones and with sinus histiocytes and endothelial cells. It has also tumor specificity and reactivity with normal nonlymphoid tissue. Cellular Localization: Cell membrane.
Isotype	IgG2b
Formulation	State: Supernatant State: Liquid Serum Free Culture Supernatant Stabilizer: 0.7% BSA Preservative: 0.09% Sodium Azide
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C.
Background	HLA DR, like other MHC class II molecules, is a transmembrane glycoprotein composed of an alpha chain (36 kDa) and a beta chain (27 kDa). It is expressed primarily on antigen presenting cells such as B lymphocytes, monocytes, macrophages, thymic epithelial cells and activated T lymphocytes. Three loci, DR, DQ and DP, encode the major expressed products of the human class II region. The human MHC class II molecules bind intracellularly processed peptides and present them to T helper cells. They therefore have a critical role in the initiation of the immune response.
Synonyms	HLA-DR, HLA class II histocompatibility antigen DR, MHC class II antigen DR
Note	Mol. Wt. of Antigeng: 36 kDa (alpha chain) and 27 kDa (beta chain).
Reference Data

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