Melanoma Discriminated Antigen Mouse Monoclonal Antibody [Clone ID: PAL-M2]

Specifications

Product Data
Clone Name	PAL-M2
Applications	IHC
Recommend Dilution	Immunohistochemistry on Frozen Sections: Use at 1/5-1/25 preferably in PBS.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Isolated from Human Melanoma cells.
Specificity	Detects Melanoma Discriminated Antigen in Human samples. This Monoclonal antibody clone PAL-M2 stains a minority of primary melanomas and half of the metastatic lesions tested. It rarely stains dysplastic naevi or common cellular naevi using standard immunohistochemical conditions. The antibody recognizes two protein bands in Immunoblotting with a Molecular Weight of 95-100 kD. Cross reactivity: Skin carcinomas: not detectable Dendritic cells in inflammatory infiltrates: present Sebaceous glands : present Non-cutaneous tumors: present
Isotype	IgG1
Formulation	State: Supernatant Preservative: 10mM Sodium Azide
Conjugation	Unconjugated
Storage Condition	Store undiluted (in aliquots) at -20°C. Avoid repeated freezing and thawing.
Background	Melanoma is a malignant tumor of melanocytes which are found predominantly in skin but also in the bowel and the eye (see uveal melanoma). It is one of the rarer types of skin cancer but causes the majority of skin cancer related deaths. Despite many years of intensive laboratory and clinical research, the sole effective cure is surgical resection of the primary tumor before it achieves a thickness of greater than 1 mm.
Reference Data

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