CD41 (ITGA2B) Mouse Monoclonal Antibody [Clone ID: CA3]

Specifications

Product Data
Clone Name	CA3
Applications	ELISA, IHC, WB
Recommend Dilution	Western blotting: 1/1000. Immunohistochemical on Frozen Sections. Other Immunoassays for cellular and tumor biology.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Partially purified platelet glycoprotein IIb/IIIa complex. Hybridoma produced by fusion between myeloma cells and Balb/c spleen cells.
Specificity	The antibody clone CA3 reacts with the alpha-IIb-subunit of the beta-integrins. Reacts specifically with platelets, megakaryocytes and leukemic cells able to megakaryocytic differentiation.
Isotype	IgG1
Formulation	PBS State: Ig Fraction State: Liquid Ig fraction Stabilizer: 1.0% BSA Preservative: 0.09% Sodium Azide
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C.
Gene Name	integrin subunit alpha 2b
Database Link	Entrez Gene 3674 Human UniProt ID P08514
Background	Integrin alpha 2b (CD41) is a calcium-dependent, noncovalently associated heterodimer and contains a heavy chain (GPIIb alpha) and a light chain (GPIIb beta) linked by a single disulfide bond. The Integrin alpha 2B chain interacts with the Integrin beta 3 subunit/CD61 to form the platelet glycoprotein complex, gpIIb/IIIa. It is expressed on platelets and megakaryocytes. Ligands for the gpIIb/IIIa heterodimer include fibrinogen, von Willebrand factor, fibronectin, vitronectin, and thrombospondin. The gpIIb/IIIa complex is the major Integrin on platelets and is important for platelet adhesion and aggregation. The alpha IIb-Integrin subunit is a specific marker for platelets and megakaryocytes and can be utilized for this purpose in various immunological techniques.
Synonyms	Integrin alpha-IIb, GP2B, ITGAB, GPalpha IIb
Reference Data

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.