Alkaline Phosphatase (ALPP) Mouse Monoclonal Antibody [Clone ID: V17.1]

Specifications

Product Data
Clone Name	V17.1
Applications	ELISA, IHC
Recommend Dilution	ELISA. Immunohistochemistry on Frozen Sections.
Host	Mouse
Clonality	Monoclonal
Immunogen	A BALB/c Mouse was immunized with Alkaline Phophatase.
Specificity	This antibody clone V17.1 reacts with alkaline phosphatase, an enzym widely used in immunodection tests. Can be used for detection of Alkaline Phophatase and for amplification of Alkaline Phophatase reactions (APAP).
Isotype	IgG1
Formulation	PBS State: Purified State: Liquid purified IgG fraction Preservative: 0.05% Sodium Azide
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	alkaline phosphatase, placental
Database Link	UniProt ID P05187
Background	There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. The exact physiological function of the alkaline phosphatases is not known. A proposed function of this form of the enzyme is matrix mineralization; however, mice that lack a functional form of this enzyme show normal skeletal development. This enzyme has been linked directly to hypophosphatasia, a disorder that is characterized by hypercalcemia and includes skeletal defects. The character of this disorder can vary, however, depending on the specific mutation since this determines age of onset and severity of symptoms. Alternatively spliced transcript variants, which encode the same protein, have been identified for this gene.
Synonyms	PLAP-1, Alkaline phosphatase Regan isozyme
Reference Data

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