Golgi zone Mouse Monoclonal Antibody [Clone ID: AE-6]

Specifications

Product Data
Clone Name	AE-6
Applications	IHC
Recommend Dilution	Flow Cytometry. Immunofluorescence. Immunohistochemistry on Frozen and Paraffin Sections: AE-6 produces a diffuse staining pattern of the Golgi zone in normal and malignant cells and can be used for paraformaldehyde fixed or frozen tissue or cell preparations and formalin fixed, paraffin-embedded tissue sections. Recommended Positive Control: Tonsil.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	A BALB/c mouse was immunized with Su-DHL-1 large lymphoma cells. The isolated splenocytes were fused with mouse myeloma cells.
Specificity	The Monoclonal antibody AE-6 recognizes an antigen found in the golgi zone of Human cells. It can also be used as a marker of the golgi zone in subcellular fractions.
Isotype	IgG1
Formulation	PBS State: Purified State: Liquid purified Ig fraction Preservative: 0.05% Sodium Azide
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Background	The Golgi apparatus is an organelle present in all eukaryotic cells that forms a part of the endomembrane system. The primary function of the Golgi apparatus is to process and package macromolecules synthesized by the cell for exocytosis or use within the cell. The Golgi is made up of a stack of flattened, membrane-bound sacs known as cisternae, with three functional regions: the cis face, medial region, and trans face. Each region consists of various enzymes that selectively modify the macromolecules passing though them, depending on where they are destined to reside. Several spherical vesicles that have budded off of the Golgi are present surrounding the main cisternae. The Golgi tends to be more pronounced and numerous in cells that make and secrete many substances such as plasma B cells. Golgi markers are important in biology research as they aid in the behavioral and functional analysis of this dynamic organelle.
Synonyms	Golgi Marker, Golgi Body
Reference Data

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