BCL3 Hamster Monoclonal Antibody [Clone ID: Ham150-3.5]

Specifications

Product Data
Clone Name	Ham150-3.5
Applications	ELISA
Recommend Dilution	This Clone has been described to work in ELISA, Western Blot and Flow Cytometry.
Reactivity	Human, Mouse
Host	Hamster
Clonality	Monoclonal
Immunogen	Recombinant Bcl-3-6-histidine tag from Armenian Hamster. Fusion Partner: SP2/0 myeloma.
Specificity	Recognizes B-cell Leukemia/lymphoma 3
Isotype	IgG1
Formulation	PBS containing 0.02% Sodium Azide as preservative and EIA grade BSA as a stabilizing protein to bring total protein concentration to 4-5 mg/ml. Label: Biotin State: Liquid purified IgG fraction.
Concentration	lot specific
Purification	Protein G Affinity Chromatography.
Conjugation	Biotin
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	B-cell CLL/lymphoma 3
Database Link	Entrez Gene 602 Human UniProt ID P20749
Background	B cell Lymphoma 3 is a member of the IkB subfamily of inhibitors. This subfamily is part of the NF-kB transcription factor protein family and it is suggested that a balance in the concentration of various NF-kB family members regulates apoptosis and survival of activated T cells. Bcl-3 has been shown to have versatile functions such as cytoplasmic activation of p50 homodimers, translocation to the nucleus, and modulation of the transcriptional machinery in the nucleus. Bcl-3 activity often relies on several nuclear interacting proteins such as Tip60, Jab1, Bard1, and Pirin. The Mouse Bcl-3 coding region exhibits 80% homology with Human Bcl-3 which is associated with human B-cell chronic lymphocytic leukemias (CLLs). Bcl-3 is detected in various tissues such as spleen and other lymphoid organs.
Synonyms	BCL3, BCL4, D19S37
Reference Data
Protein Families	Druggable Genome, Transcription Factors

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