Thrombomodulin (THBD) Mouse Monoclonal Antibody [Clone ID: B-A35]

Specifications

Product Data
Clone Name	B-A35
Applications	FC
Recommend Dilution	Flow Cytometry: Use 10 µl to label 10e6 cells or 100 µl of whole blood.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	TF1 cell line.
Specificity	Recognises the soluble antigen. Recognises Thrombomodulin (TM), a 105 kDa protein.
Isotype	IgG1
Formulation	PBS containing 5% BSA as stabilizer and 0.09% Sodium Azide as preservative Label: FITC State: Liquid purified IgG fraction
Purification	Ion Exchange Chromatography
Conjugation	FITC
Storage Condition	Store the antibody undiluted at 2-8°C.
Gene Name	thrombomodulin
Database Link	Entrez Gene 7056 Human UniProt ID P07204
Background	CD141/Thrombomodulin is an exclusively endothelial cell surface glycoprotein that forms a 1:1 complex with thrombin. Binding of thrombin to this high-affinity receptor alters its specificity toward several substrates. The complex activates protein C approximately 1000 times faster than thrombin alone. Activated protein C degrades clotting factors V and VIII; thus, thrombomodulin converts thrombin into a physiologic anticoagulant. Thrombomodulin is also found in the circulatory and urinary systems, the physiologic significance of this is obscure.
Synonyms	Thrombomodulin, THRM, Fetomodulin
Reference Data
Protein Families	Druggable Genome, Transmembrane
Protein Pathways	Complement and coagulation cascades

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