IL8 (CXCL8) Mouse Monoclonal Antibody [Clone ID: B-K8]

CAT#: AM31352AF-N

IL8 (CXCL8) mouse monoclonal antibody, clone B-K8, Azide Free



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CNY 7,183.00


货期*
5周

规格
    • 500 ug

Product images

Specifications

Product Data
Clone Name B-K8
Applications FC, FN
Recommend Dilution Flow Cytometry (Intra-cytoplasmic).
Fuctional Assay: Blocks IL-8 induced chemotaxis of Human neutrophils.
Reactivity Human
Host Mouse
Clonality Monoclonal
Immunogen Recombinant Human IL-8
Specificity Recognises both natural and recombinant IL-8.
Formulation PBS, Sterile-filtered through 0.22 µm and treated to remove endotoxins.
Carrier and preservative free
State: Azide Free
State: Liquid purified IgG fraction
Concentration lot specific
Purification Ion Exchange Chromatography
Conjugation Unconjugated
Storage Condition Store the antibody undiluted at 2-8°C.
Gene Name C-X-C motif chemokine ligand 8
Background IL8 is a member of the CXC chemokine family. This family of small basic heparan-binding proteins are proinflammatory and primarily mediate the activation and migration of neutrophils into tissue from peripheral blood.
This chemokine is one of the major mediators of the inflammatory response and is secreted by several cell types in response to an inflammatory stimulus. It functions as a chemoattractant, and is also a potent angiogenic factor. IL8 attracts neutrophils, basophils, and T-cells, but not monocytes.
Cystic fibrosis (CF) is characterized by severe lung inflammation. The inflammatory process is believed to be caused by massive overproduction of the proinflammatory protein IL8, and the high levels of IL8 in the CF lung are therefore believed to be the central mechanism behind CF lung pathophysiology.
Synonyms CXCL8, Protein 3-10C, Emoctakin, GCP1, MDNCF, MONAP, NAP1
Reference Data
Protein Families Druggable Genome, Secreted Protein, Transmembrane
Protein Pathways Bladder cancer, Chemokine signaling pathway, Cytokine-cytokine receptor interaction, Epithelial cell signaling in Helicobacter pylori infection, NOD-like receptor signaling pathway, Pathways in cancer, RIG-I-like receptor signaling pathway, Toll-like receptor signaling pathway
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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