IL23 (IL23A) Mouse Monoclonal Antibody [Clone ID: B-Z23]

Specifications

Product Data
Clone Name	B-Z23
Applications	FN, IHC
Recommend Dilution	Functional Assays: Neutralises the bioactivity of rhIL-23 on Mouse splenocytes C57BI/6 (measurement of mIL-17 or mIL-22 production). Immunohistochemistry on Paraffin Embedded Sections.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant Human IL-23 (sub-unit p19)
Specificity	This antibody recognizes both recombinant and natural IL-23, p19 sub-unit.
Isotype	IgG1
Formulation	Phosphate-buffered saline. Sterile-filtered through 0.22 µm and treated to remove endotoxins. Carrier and preservative free. State: Azide Free State: Liquid purfied IgG fraction
Concentration	lot specific
Purification	Ion Exchange Chromatography
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C.
Gene Name	interleukin 23 subunit alpha
Database Link	Entrez Gene 51561 Human UniProt ID Q9NPF7
Background	The p19 shares sequence similarity with IL-6 subfamily members and is distantly related to the p35 subunit of IL-12. It shows no biological activity by itself; instead, it combines with the p40 subunit of IL-12 to form a biologically active, composite cytokine, IL-23. IL-23 shares some in vivo functions with IL-12, including the activation of the transcription factor Stat4. Similar to IL-12, human IL-23 stimulates IFN-g production and proliferation in PHA blast T cells, as well as in CD45RO (memory) T cells. Ubiquitous transgenic expression of the IL-23 subunit p19 induces multiorgan inflammation, runting, infertility, and premature death.
Synonyms	IL-23 subunit alpha, SGRF, Interleukin-23 subunit p19, IL-23p19
Reference Data
Protein Families	Druggable Genome, Secreted Protein
Protein Pathways	Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway

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