DcR1 (TNFRSF10C) Mouse Monoclonal Antibody [Clone ID: B-D44]

Specifications

Product Data
Clone Name	B-D44
Applications	FN
Recommend Dilution	Functional Assay: Inhibits TRAIL binding to TRAIL R3.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant Human TRAIL R3/Fc chimera. Hybridoma: Myeloma X63/AG.8653 x Balb/c spleen cells.
Specificity	Recognizes the soluble antigen. Recognizes the 75-90kDa protein.
Isotype	IgG1
Formulation	Phosphate-buffered saline without Carrier and preservatives. This prodcut is sterile-filtered through 0.22 µm and treated to remove Endotoxins. State: Azide Free State: Liquid purified IgG fraction
Concentration	lot specific
Purification	Ion Exchange Chromatography
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C.
Gene Name	tumor necrosis factor receptor superfamily member 10c
Database Link	Entrez Gene 8794 Human UniProt ID O14798
Background	TRAIL-R3 (CD263, TR3, DcR1, LIT, TRID), expressed mainly on neutrophils, belongs to receptors of TRAIL, a TNF-like membrane cytotoxic protein that induces apoptosis in many tumour cells, but not in normal cells. TRAIL-R3, however, is a GPI-anchored protein that lacks cytoplasmic death domain, thus it is unable to induce apoptosis and serves as a negative regulator of apoptotic signaling by competing for binding of TRAIL with death receptor 5 (DR5).
Synonyms	Decoy receptor 1, TNFRSF10C, DCR1, LIT, TRID, TRAIL receptor 3, TRAIL-R3
Reference Data
Protein Families	Druggable Genome, Transmembrane
Protein Pathways	Apoptosis, Cytokine-cytokine receptor interaction, Natural killer cell mediated cytotoxicity

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