TNFSF12-TNFSF13 Mouse Monoclonal Antibody [Clone ID: CARL-1]

Specifications

Product Data
Clone Name	CARL-1
Applications	FC, FN
Recommend Dilution	Flow cytometry. Functional application: Neutralization.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Human CD255-transfected 2PK-3 cells
Specificity	This antibody recognizes CD255 / TWEAK, a type II transmembrane protein of the TNF superfamily able to weakly induce apoptosis in many cell types.
Isotype	IgG3
Formulation	Tris buffered saline (TBS), pH 8.0, 15 mM sodium azide. State: Low Endotoxin State: Liquid Ig fraction
Concentration	lot specific
Purification	Protein-A affinity chromatography (> 95% pure by SDS-PAGE)
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C. DO NOT FREEZE!
Gene Name	TNFSF12-TNFSF13 readthrough
Database Link	Entrez Gene 407977 Human UniProt ID O43508
Background	CD255 / TWEAK (TNF-related weak inducer of apoptosis), a type II transmembrane protein expressed as membrane-bound and secreted form, can induce apoptosis in many tissues and cell lines through its receptor CD266 / TWEAK R. On the other hand, in endothelial cells this interaction can induce proliferation and promote angiogenesis including neovascularization of tumours. CD255 can act in a juxtacrine manner to initiate cellular responses, and induces secretion of pro-inflammatory cytokines. Besides CD266, CD255 may also bind to DR3.
Synonyms	APO3 ligand, APO3L, DR3LG
Reference Data

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