Melatonin Related Receptor (GPR50) Mouse Monoclonal Antibody [Clone ID: 1A3]

Specifications

Product Data
Clone Name	1A3
Applications	IHC
Recommend Dilution	Immunohistochemistry on paraffin sections: 5 µg/ml. Positive control: Human placenta.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	DNA vaccine
Specificity	This antibody detects Human GPR50.
Isotype	IgG1
Formulation	Phosphate buffered saline pH 7.2 (PBS) State: Purified State: Lyophilized affinity purified Ig fraction Stabilizer: 5 mg/ml bovine serum albumin (BSA) Preservative: 0.1% Kathon
Purification	Protein G
Conjugation	Unconjugated
Storage Condition	Store lyophilized at 2-8°C for 6 month or at -20°C long term. After reconstitution store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C long term. Avoid repeated freezing and thawing.
Gene Name	G protein-coupled receptor 50
Database Link	Entrez Gene 9248 Human UniProt ID Q13585
Background	GPR50 or me latonin - related receptor is a 617 amino acid protein that belongs to the G - protein coupled receptor 1 family, containing one disulfide bond. GPR50 does not bind melatonin and its end ogenous ligand is still unknown. Nevertheless, this receptor has been shown to behave as an antagonist of the melatonin receptor MT 1. GPR50 has been identified as a genetic risk factor for bipolar disorder and major depression in women, and it has been linked to neurite outgrowth, lipid metabolism, stress response and energy homeostasis and torpor. Its expression seems to be limited to brain, particularly the hypothalamus and pituitary.
Synonyms	Melatonin-related receptor, G protein-coupled receptor 50, H9
Reference Data

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