Amyloid beta (N-term) Mouse Monoclonal Antibody [Clone ID: NT 5B8]

Specifications

Product Data
Clone Name	NT 5B8
Applications	ELISA, WB
Recommend Dilution	ELISA. Western Blot: 1/5000.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Human beta amyloid peptide 1-42
Specificity	This antibody recognizes the N-terminal sequence of human beta amyloid peptide 40 and peptide 42.
Isotype	IgG1
Formulation	0.01M PBS pH7.2 State: Aff - Purified State: Lyophilized Ig purified fraction
Reconstitution Method	Double distillated water is recommended and to adjust the final concentration to 1.00 mg/ml.
Purification	Affinity Chromatography on Protein G
Conjugation	Unconjugated
Storage Condition	Upon receipt, store undiluted (in aliquots) at -20°C. Avoid repeated freezing and thawing.
Background	Amyloid beta precursor protein gene (ABPP) encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Multiple transcript variants encoding several different isoforms have been found for this gene. Isoform APP695 is the predominant form in neuronal tissue, isoform APP751 and isoform APP770 are widely expressed in nonneuronal cells. Isoform APP751 is the most abundant form in T lymphocytes. ABPP is expressed in all fetal tissues examined with the highest levels in brain, kidney, heart and spleen with weak expression observed in liver; ABPP is induced during neuronal differentiation. In the adult brain, highest expression of ABPP gene is found in the frontal lobe of the cortex and in the anterior perisylvian cortex opercular gyri; moderate expression in the cerebellar cortex, the posterior perisylvian cortex opercular gyri and the temporal associated cortex. Weak expression is found in the striate, extra striate and motor cortices. Mutations in ABPP have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy).
Reference Data

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