Amyloid beta (N-term) Mouse Monoclonal Antibody [Clone ID: NT 7H7]

Specifications

Product Data
Clone Name	NT 7H7
Applications	ELISA
Recommend Dilution	ELISA: Capture antibody to detect A beta 42 or A beta 40 in sandwich ELISA. The matched detection antibody clones are: CA9 10C11 for A beta 42 assay, and CV9 7B10 for A beta 40 assay.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Full length human beta amyloid peptide 42
Specificity	This antibody recognizes the N-terminal sequence (DAEFRHDS) of beta amyloid peptides, and full length beta amyloid peptide 40, 42 and 43.
Isotype	IgG2b
Formulation	0.01M PBS pH7.2 State: Aff - Purified State: Lyophilized Ig fraction
Reconstitution Method	Use double distillated water to reconstitute the antibody.
Purification	Protein G affinity purified
Conjugation	Unconjugated
Storage Condition	Store at -20 °C. Avoid repeated freezing and thawing.
Background	Beta amyloid, often abbreviated as A-beta, is a protein that builds up in the brains of persons with Alzheimer's disease, collecting in clumps called plaques or senile plaques. While some researchers question whether beta amyloid is the cause of the dementia, most agree that it is involved in the disruption of thinking that is a hallmark of the disease. In some cases of familial Alzheimer's disease, mutations in genes for the proteins called the presenilins lead to increased production of amyloid. Researchers have been looking at how presenilin-1 in particular contributes to the excess buildup of beta amyloid. Presenilin-1 apparently acts to increase the activity of gamma-secretase, an enzyme that changes a normal protein (amyloid precursor protein or APP) into beta amyloid itself. Furthermore, presenilin-1 might be gamma-secretase.
Reference Data

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