Benzo(a)pyrenediol-epoxide (BPDE) Mouse Monoclonal Antibody [Clone ID: 8E11]

Specifications

Product Data
Clone Name	8E11
Applications	ELISA
Recommend Dilution	Immunoassays (detector). Useful for Immunopurification.
Host	Mouse
Clonality	Monoclonal
Specificity	The monoclonal antibody 8E11 recognizes free BPDE and DNA adducts.
Isotype	IgG1
Formulation	PBS State: Purified State: Liquid 0.2 µm filtered Ig fraction Stabilizer: 0.1% bovine serum albumin Preservative: 0.02% sodium azide
Concentration	lot specific
Purification	Protein G
Conjugation	Unconjugated
Storage Condition	Store at 2 - 8 °C.
Background	A number of chemicals, including polycyclic aromatic hydrocarbons (PAHs), have been shown to bind to DNA. This DNA damage can occur both early and late in the malignant process, thereby acting as an initiator and assisting in the progression of tumors. PAHs are released into the environment following incomplete combustion of organic materials. The most common sources of PAHs are from smoking and from consuming broiled or grilled foods. Human exposure to PAHs comes from various occupational, environmental, dietary and medicinal sources. Benzo[a]pyrene is a representitive PAH. Antibodies to benzo[a]pyrenediol-epoxide modified DNA (BPDE-DNA) can be used to identify polycyclic aromatic hydrocarbon (PAH)-DNA adducts. Exposure to this group of compounds is believed to be carcinogenic.
Synonyms	polycyclic aromatic hydrocarbon, PAH
Reference Data

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